Clinical Studies

Over 28,000 Clinical Studies Worldwide Have Shown The Benefits of HGH

Anti-aging

A clinical observation carried out by Grace Wong MD. of Genetech Research and Development Centre proved that, HGH defy oxidization of our body, it is the ultimate weapon to fight against aging. According to her, as we age, cell proteins suffer ever accumulating damage. This is, in large part, caused by ever-increasing incidence of free radicals released during normal cellular activity. Wong says that HGH can actually activate a cellular defense force of protease inhibitors. Thus, unlike antioxidants, HGH does not just reduce cellular damage; it can actively promote the healing and regeneration of cells. That's why we can live younger and longer.

Increased Vitality & Brain Function

Not only HGH reinvigorates the mind, it can also reverse the attitudes, outlook and expectations associated with aging. GH raises energy levels, improves slow-wave sleep and elevates mood. In a startling report, Johannsson's team found that growth hormone actually changed the levels of certain neuro-transmitters in the human brain, raising the level of B-endorphin, which has been called the brain's own opiate, and lowering the level of dopamine, which is associated with feelings of agitation. This is similar to the concentrations these neurotransmitters one sees in. antidepressants, says Bengtsson, who was part of the research team. In other reports, GH appears to reduce stress, improve focus and concentration and build self-esteem and self—confidence. GH can reverse decline in memory and cognitive performance. In a study of adult-male patients deficient in GH, Dutch researchers headed by Jan Berend Deijiem, M.D, found that GH deficiency is associated with impairments in iconic memory (the ability to process flashes of .infoifmation), short term memory, long term memory, .and perceptual motor sklls such as hand-eye coordination. Interestingly, lower levels of IGF-l; the lower the patient's IQ and education level.

Build Muscle

Medical Studies have proven that positive gains occur only while GH is being secreted. GH significantly increases the effects of exercise and muscle building, including energy, muscle strength, stamina and endurance. Dr. Daniel Rudrnan has conducted a double blind clinical trail on a group of men between the ages of 60 to 80 years old, and reported in the New England Journal of Medicine, July 5, 1990 issue, showed that on average the men lean body mass increased by 8.8%. Studies at St. Thomas Hospital in London showed that "there is a tremendous increase in muscles and you won‘t believe how hard they are". L.Cass Terry, MD. also found that Growth Hormone, "made a tremendous difference in my fat composition and body configuration in less than two months".

Increased Libido

The decline of male potency parallels the decline of growth hormone release in our body with GH levels and sexual potency at their peak during puberty and already decreasing in young manhood, until by age of 80, 75% of men are incapable of getting or sustaining erections. The Massachusetts Male Aging Study (MMAS), in a random sampling of 1,290 men, found that complete erectly dysfunction increased from 5% at age forty to 15% at age seventy-nine, with difficulty in having erections experienced by 52% in the older age group. In the first clinical analysis of the effects of HGH replacement in 202 people, including 172 men, by L. Cass Terry and Edmund Chein, fully three-quarters of the participants said that they had an increase in sexual potency and frequency. And 62% of the men reported that they were able to maintain an erection for a longer period of time. Since the vast majority en- GH therapy report an increase in sexual appetite and performance, there is strong evidence that growth hormone plays- a pivotal role in sexual health.

Erectile Dysfunction

Nutrients such as L-Arginine are fast emerging as one of the most potent nutraceuticals yet described. It works, when our body breaks it down, in the process releasing a simple gas called Nitric Oxide (NO), :1 gas that last no more than few seconds at a time but which scientists now know is one of the single most critical molecules in our body. Over the last decade, researches have made a series of truly revolutionary discoveries about the critical functions NO plays. Some of them are to enhance the HGH release and stimulate erections in men with erectile dysfunction. Erection during sexual arousal is the result of a complex biochemical chain reaction. A key step in the process occurs when endothelial cells in penile blood vessels increase production of NO from arginine. This, in turn, end up triggering blood flow into the cavernous chambers of the penis. As the pressure builds, it presses against penile veins, reducing outflow and resulting an erection. Majority of cases of ED, is associated with a physical condition that contributes to a failure of arginine/NO mechanism in the blood vessels of the penis.

Decreased Body Fat And Increased Lean Muscle

GH does something no other weight-loss regimen does: It recontours the body, melts away fat and building muscle. In many cases, people look like they have shed years away along with the fat they have lost. Even better, the greatest loss occurs in deep belly fatty area associated with increased risk of heart attack. In a six month placebo-controlled trial at St. Thomas Hospital in London of 24 adults with GH deficiency, the hormone treated group had no net change in weight, but lost an average 12.5 pounds of fat and gained an average of 12.1 pounds of lean body mass. GH may be the most effective fat—loss regimen ever discovered. 

In a double-blind, placebo-controlled, crossover study on overweight woman, GH caused an average loss of more than 4.6 pounds on body fat, mostly in the abdomen. Most diet cause loss of muscle along with fat, but in this study, the women's lean body mass increased by 6.6 pounds. In two double-blind, placebo controlled studies by David Clemmon, M.D at the University of North Carolina in Chapel Hill, growth hormone and dieting caused some 25% acceleration in the rate of fat loss, above and beyond the effect of dieting alone. In the 11-week treatment period, the GH-treated subjects lost 30 to 32 pounds in the controls, And while the controls lost muscle along with their fat, the treated group maintained their body tone.

Improve Elasticity and Smoothness Of Complexion

"It is cosmetic surgery in a bottle, smoothing out facial wrinkles; elasticity, thickness and contours of the skin are restored to youthful conditions" Dr. Ronald Klatz, MD, President of the American Academy of Anti-Aging Medicine in his book "Grow Young With HGH". HGH will help to maintain a moisturized skin, that is elastic and smooth, a complexion without wrinkles and looks younger. This is because HGH helps to attain fluidity in the skin, stimulate metabolism, the process which is slowing and deteriorating in aging skin. According to an explanation by Roy Dittman, MD, a specialist in aging, that the amount of HGH in a body determines its influence. Some might not achieve immediate results and has to wait for a longer time to realize the changes. Patience is important to enable the hormone to do its work. HGH is a smart hormone, alert and a quick learner. It has the ability to identify malfunction and will quickly act upon recovering it almost immediately.

Prevent Osteoporosis

While GH therapy is used to grow the skeletal bones of children who are deficient in the hormone, results in adults have been inconsistent. Dr. Daniel Rudman in his double blind trail found that 6 months of GH treatment increased the density of the lumbar vertebrae by 1.6% in men over 65, but there was no increase in the arm or the femur of the leg. Several groups have reported an increase in bone mineral content.

Improved Bone Density

Recently, Swedish scientists led by Gudmundur Johannson, M.D. studied 44 men and women between 23 and 66 years of age who were severely deficient in growth hormone. Two years of GH therapy caused significant increases in the density of the bones that form the hip joint and the vertebrae of the lower spine. The studies also showed an increase in calcium, a calcium-binding bone protein called osteocalcin, as well as two types of collagen, which are markers of bone formation. The researchers estimate that they have reduced the possibility of fracture so that it now equals that of normal healthy controls.

Improved Cardiac Function

GH therapy improves cardiac function and protects against cardiovascular disease in a number of ways. It reduces body fat, particularly in the abdominal region, which has been shown to be highly correlated with increased risk of heart attack. GH also improves blood cholesterol profiles, raising high-density lipoproteins (HDL) and lowering low-density lipoproteins (LDL) and reduces diastolic blood pressure by about 10%, without affecting systolic pressure. Treatment with growth hormone has reversed heart failure. In a 1996 study in the New England Journal of Medicine, GH given to 7 patients - 5 men and 2 women with moderate-to-severe heart faliure- increased the thickness of the left ventricular wall, enhanced the ability of the heart to contract and pump blood, reduced the oxygen requirement of the heart, improved exercise capacity and enhanced quality of life.

Improved Lung Function

HGH had improved heart lung function by increasing the ability of patients to exercise, raising their maximum oxygen uptake and increasing their stroke volume and cardiac output. David Clemmons, chief of endocrinology at the University of North Carolina School of Medicine in Chapel Hill, found that three weeks of GH injections in patients in the latter stages of chronic obstructive pulmonary force by 10 to 12mm on average and increased maximum expiratory force. "If we were as impaired as these patients,  going from 25mm to 38mm would be a help” says Clemmons, who believes that GH is a promising treatment for emphysema and other forms of chronic obstructive pulmonary diseases.

Improved Cholesterol Levels

In 1997, a study found that in normal adults, the more human growth hormone they had, the higher their level of HDL (healthy) cholesterol. HDL cholesterol is the good cholesterol that sucks the LDL (unhealthy) cholesterol from the walls of the arteries and carries it to the liver for disposal from our body. Human growth hormone has been shown to increase the healthy HDL cholesterol and lower the dangerous LDL cholesterol thereby decreasing the risk of clogged arteries.

A study on heart disease done by Bengtsson of the University of Goteborg showed that the 333 patients he tested with severe growth hormone deficiency had normal cholesterol levels, however, when he split the cholesterol between LDL and HDL cholesterol, the levels showed a different story. These growth hormone deficient patients had very high levels of the very harmful LDL cholesterol and very low levels of the good, protective HDL cholesterol. Bengtsson concluded that this could help to explain the double increase in cardiovascular disease experienced by this group of patients After 6 months of HGH therapy, these patients LDL cholesterol level was decreased and their HDL cholesterol level was increased, which is the desired effect.

Improved Immune System

In 1985, Keith Kelley, M.D., a research immunologist at the University of Illinois at Urban~Charnpaign, showed that HGH could re-grow the shriveled thymus gland in old rats until it was as large and robust as in young rats. Kelley's work was confirmed by Israeli scientist who used bovine growth hormone to reverse thymus shrinkage in mice and similar results have been demonstrated in dogs. Immune activities that improves are the manufacture of new antibodies ;_increased  production of T-cells and interleukin 2 ; greater proliferation and activity of lymphocytes; higher activity of natural killer cells; stimulation of macrophages; increased maturation of neutrophils; and increased production of red blood cells.

HGH and Diabetes

There had been some concern that HGH is the elevation of blood sugar, could make diabetes worse, since growth hormone is known to antagonize the effects of insulin. Growth hormone mobilizes body fat, causing our fat cells to break themselves down and release free fatty acids into the blood stream. These free fatty acids are energy molecules which can be taken up by organs and many of our organs to be used for energy. When our muscles are consuming free fatty acids as a fuel, they are far less interested in sugar, therefore they tend to resist the effects of insulin, and extract less sugar from the blood. At the same time, growth hormone can increase glucose output from the liver to the blood. This combination of effects can raise blood sugar and raise insulin levels, neither of which is good. Fortunately, this is only a problem in people who eat a diet high in sugar and starch, and do little exercise.

But, recent studies have shown that far from worsening diabetes, HGH may actually help to improve diabetes Dr. Ronald Klatz, author of the book, "Growing Young with HGH" writes that "Previous studies, including one done by a Dr. Rudman, showed that growth hormone caused increased insulin resistance, making blood glucose rise, and contraindicating its use in diabetic patients". Dr. Bengtsson showed the same thing in a short-term study of 6 weeks of growth hormone treatment. But after six months, he found the insulin sensitivity returned to where it was before the patient started treatment. In other words, growth hormone did not increase blood glucose or make the patient diabetic. It may be, says Bengtsson "that the improvement in body composition after six months offset any negative effects that growth hormone has on insulin". 

He goes on to write that, “There are some indications. that growth hormone may even improve diabetes". Blackman, Who is looking at the effects of growth hormone on blood glucose as part of his NIA study at John Hopkins, says, “We postulate the case that when elderly people are in a low state of growth hormone, they have more intra abdominal fat, their insulin acts less well, and they have a tendency to higher blood sugar. If they are given growth hormone replacement carefully, rather than excessively, their blood sugars should improve rather than worsen".